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HARRISON’s Principles of Internal Medicine 20th Edition

Harrison’s Principles of Internal Medicine

The focus of medical education worldwide is shifting from the classic structure/function/disease approach to an integrated, often case-based approach in which basic and population sciences are specifically linked to the practical diagnosis and management of disease. Many of the updates and changes described here have been undertaken with the modern educational and clinical environments in mind. This new edition offers a thoroughly updated presentation of the classic pathophysiologic basis of clinical medicine and details the cutting-edge methods and tools that are now available for the assessment of symptoms and the effective management of diseases in the modern patient-care environment. The text is supplemented by germane new photographs, radiographs, illustrations, atlases, patient-care algorithms, tables, and practical demonstrative videos. In the interest of producing the most practical format possible for the 19th edition, a new system of referencing has been used.
Detailed bibliographic listings, with summaries of articles’ relevance to practice, appear in the online edition, replacing the general and limited collection of Suggested Readings that appeared in the prior print editions. The 19th edition of Harrison’s is designed for accessibility and flexibility. The print textbook is available in two volumes. Volume 1 focuses on the foundations of medicine and the understanding and assessment of cardinal disease manifestations; Volume 2 focuses on specific diseases, by system. This functional division will be helpful to students who are mastering the basis of clinical medicine and to clinicians who are more focused on gaining an advanced understanding of mechanisms and patient care in specific diseases. In terms of digital media, Harrison’s is now available as an eBook on multiple platforms, as an enhanced “app” developed especially for tablet and smartphone devices that offer high-definition resolution of multimedia content and interactive features, and as an updated online edition. All of these options provide access to our numerous e-chapters as well as to videos and atlases. Additional resources include the Harrison’s Self-Assessment and Board Review, a useful study guide based on information in the 19th edition, and the Harrison’s Manual of Medicine, a pocket version of Harrison’s Principles of Internal Medicine. A new Harrison’s collection of case vignettes emphasizing differential diagnostic considerations in the assessment of cardinal manifestations will also be available. Advances in medical science have been spectacular since Harrison’s was first published in 1949.

Harrison’s Principles of Internal Medicine

Harrison’s Principles of Internal Medicine

Harrison’s Principles of Internal Medicine is an American textbook of internal medicine. Although it is aimed at all members of the medical profession, it is mainly used by internists and junior doctors in this field, as well as medical students. It is widely regarded as one of the most authoritative books on internal medicine and has been described as the “most recognized book in all of medicine.

Table of Contents :

Part 1: General Considerations in Clinical Medicine
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
Section 2: Alterations in Body Temperature
Section 3: Nervous System Dysfunction
Section 4: Disorders of Eyes, Ears, Nose, and Throat
Section 5: Alterations in Circulatory and Respiratory Functions
Section 7: Alterations in Renal and Urinary Tract Function
Section 9: Alterations in the Skin
Section 10: Hematologic Alterations

Part 3: Genes, the Environment, and Disease
Part 4: Regenerative Medicine
Part 5: Aging

Part 6: Nutrition and Weight Loss
Section 1: Neoplastic Disorders
Section 2: Hematopoietic Disorders

Part 8: Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
Section 2: Clinical Syndromes: Community-Acquired Infections
Section 3: Clinical Syndromes: Health Care-Associated Infections
Section 4: Approach to Therapy for Bacterial Diseases
Section 5: Diseases Caused by Gram-Positive Bacteria
Section 6: Diseases Caused by Gram-Negative Bacteria
Section 7: Miscellaneous Bacterial Infections
Section 8: Mycobacterial Diseases
Section 9: Spirochetal Diseases
Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
Section 11: Viral Diseases: General Considerations
Section 12: Infections Due to DNA Viruses.
Section 13: Infections Due to DNA and RNA Respiratory Viruses
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
Section 15: Infections Due to RNA Viruses
Section 16: Fungal Infections
Section 17: Protozoal and Helminthic Infections: General Considerations
Section 18: Protozoal Infections
Section 19: Helminthic Infections

Part 9: Terrorism and Clinical Medicine

Part 10: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
Section 2: Diagnosis of Cardiovascular Disorders
Section 3: Disorders of Rhythm
Section 4: Disorders of the Heart
Section 5: Coronary and Peripheral Vascular Disease

Part 11: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
Section 2: Diseases of the Respiratory System

Part 12: Critical Care Medicine
Section 1: Respiratory Critical Care
Section 3: Neurologic Critical Care
Section 4: Oncologic Emergencies

Part 14: Disorders of the Gastrointestinal System
Section 1: Disorders of the Alimentary Tract
Section 2: Liver and Biliary Tract Disease
Section 3: Disorders of the Pancreas

Part 15: Immune-mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System in Health and Disease
Section 2: Disorders of Immune-Mediated Injury
Section 3: Disorders of the Joints and Adjacent Tissues

Part 16: Endocrinology and Metabolism
Section 1: Endocrinology
Section 2: Reproductive Endocrinology.
Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
Section 4: Disorders of Bone and Mineral Metabolism
Section 5: Disorders of Intermediary Metabolism

Part 17: Neurologic Disorders
Section 1: Diagnosis of Neurologic Disorders
Section 2: Diseases of the Central Nervous System
Section 3: Nerve and Muscle Disorders
Section 4: Chronic Fatigue Syndrome
Section 5: Psychiatric and Addiction Disorders

Part 18: Poisoning, Drug Overdose, and Envenomation
Part 19: Disorders Associated with Environmental Exposures
Part 20: Clinical Procedures Tutorials
Brigham and Women’s Hospital Series
Mount Sinai School of Medicine Series
Credit: Mount Sinai School of Medicine Series: Medical Editors: Sean Sadikot and Jeremy Matloff

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Harrison’s Principles of Internal Medicine

The book is divided into 20 parts that cover broad topics such as the profession of medicine, cardinal manifestations and presentation of disease, oncology and hematology, immune-mediated, inflammatory, and rheumatological diseases, and disorders associated with environmental exposures. The parts are further divided into specific topic sections, such as pain, therapy for bacterial disease, neurologic critical care. Finally, these sections are subdivided into chapters covering conditions such as urticaria, angioedema, and allergic rhinitis, with lists of further reading suggestions. Throughout the book, there are a great number of full-color figures, algorithms, and intuitive tables to support the text. As readers become familiar with the book's format, it is very easy to use the pertinent patient management algorithm in the front cover page that refers them directly to the relevant page. There is also a listing of available videos; supplemental topics, such as microbial bioterrorism, technique of lumbar puncture; and atlases of rashes, oral manifestations of disease, and electrocardiography. An electronic version of the book is available for separate purchase through the AccessMedicinewebsite, which allows a 30-day trial subscription.

32 thoughts on “HARRISON’s Principles of Internal Medicine 20th Edition”

  1. Hii sir can plz tell me how to open it on whatsapp or save it in mobile ( i phone 6s) for future that we can read it offline too thanks for the books . Plz reply as soon as possible sir in messenger inbox.Thanks

  2. Why is the pdf automatically disappearing while opening with adobe or apple apps…..plz reload the book ….there is some defect or virus with the pdf

  3. Pls its not opening with most pdf readers, pls upload a version of harrison 20th edition opening in all pdf readers including xodo. Some defect with this pdf.

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